Welcome to Marvel Answers. What would you like to know?

It probably depends on the writer and circumstances.

Venom is stronger, faster, and far more resistant to physical damage.  On the other hand, Sabretooth is more skilled and ruthless. 

Venom has a weakness to fire that even Sabretooth could take advantage of, but on the other hand Sabretooth has tiny claws that should have a hard time piercing through the full-sized Symbiote. 

Does Sabretooth still have an adamantium skeleton? If not, Venom should probably have the advantage.

Ad blocker interference detected!

Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.